⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809737 | 0.90 | RET (0.34) | — | |
| SCHEMBL23063926 | 0.86 | RET (0.31) | — | |
| SCHEMBL23063925 | 0.83 | — | — | |
| SCHEMBL23064027 | 0.83 | CNR1 (0.31) | — | |
| SCHEMBL28524841 | 0.83 | — | — | |
| SCHEMBL23064048 | 0.78 | KCNH2 (0.31) | — | |
| SCHEMBL30809728 | 0.77 | RET (0.38) | — | |
| SCHEMBL23126465 | 0.77 | RET (0.38) | — | |
| SCHEMBL30809734 | 0.74 | RET (0.33) | — | |
| SCHEMBL23126467 | 0.74 | RET (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11932643-B2 | Substituted heterocyclic inhibitors of PTPN11 | NAVIRE PHARMA, INC. (US) | 2024-03-19 | — | — | US | disclosed |
| US-20210317122-A1 | SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11 | Cantero Therapeutics, Inc. | 2021-10-14 | — | — | US | disclosed |
| US-10954243-B2 | Substituted heterocyclic inhibitors of PTPN11 | NAVIRE PHARMA, INC. (US) | 2021-03-23 | — | — | US | disclosed |
| EP-3787627-A1 | SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11 | Navire Pharma, Inc. (US) | 2021-03-10 | — | — | EP | disclosed |