⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11136037 | 0.79 | TSHR (0.33) | — | |
| SCHEMBL9748337 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL11381188 | 0.75 | — | — | |
| SCHEMBL8956995 | 0.74 | TSHR (0.38) | — | |
| SCHEMBL170265 | 0.72 | — | — | |
| SCHEMBL4243337 | 0.72 | — | — | |
| SCHEMBL4013459 | 0.72 | — | — | |
| SCHEMBL6396783 | 0.70 | — | — | |
| SCHEMBL2210959 | 0.70 | — | — | |
| SCHEMBL5240002 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034888-B2 | Substituted 2-imidazolidones and analogs | UNIVERSITE LAVAL (CA) | 2015-05-19 | — | — | US | claimed |
| EP-2536693-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | Université Laval (CA) | 2012-12-26 | — | — | EP | claimed |
| US-20120309777-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITE LAVAL (CA) | 2012-12-06 | — | — | US | claimed |
| WO-2011100840-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITé LAVAL (CA) | 2011-08-25 | — | — | WO | claimed |
| EP-0244176-A2 | Thienopyrimidine-2,4-dione derivatives and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-04 | — | — | EP | claimed |
| WO-2006048727-A1 | PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR | PFIZER PRODUCTS INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1095044-A1 | PIPERAZYNIL PYRIMIDINE DIONE COMPOUNDS SELECTIVE FOR ADRENOCEPTORS | ABBOTT LABORATORIES (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6166019-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| US-6153614-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000004027-A1 | PIPERAZYNIL PYRIMIDINE DIONE COMPOUNDS SELECTIVE FOR ADRENOCEPTORS | ABBOTT LABORATORIES (US) | 2000-01-27 | — | — | WO | disclosed |
| US-4835157-A | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-30 | — | — | US | disclosed |
| US-4707550-A | N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0244176-A2 | Thienopyrimidine-2,4-dione derivatives and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| US-4670560-A | VASODILATING AGENTS, HYPOTENSIVE AGENTS AND/OR CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-06-02 | — | — | US | disclosed |