⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414323 | 1.00 | — | — | |
| SCHEMBL43423 | 1.00 | — | — | |
| SCHEMBL17607771 | 0.97 | TSHR (0.46) | — | |
| SCHEMBL17607541 | 0.88 | TSHR (0.43) | — | |
| SCHEMBL221838 | 0.87 | — | — | |
| SCHEMBL56451 | 0.83 | — | — | |
| SCHEMBL101443 | 0.82 | — | — | |
| SCHEMBL101463 | 0.82 | — | — | |
| SCHEMBL5793892 | 0.82 | — | — | |
| SCHEMBL198908 | 0.80 | ACE2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4025300-A1 | ATP-REGULATED POTASSIUM CHANNEL OPENERS COMPRISING GUANIDINE AND USES THEREOF | Salzman Group Ltd. (IL) | 2022-07-13 | — | — | EP | disclosed |
| WO-2021044413-A1 | ATP-REGULATED POTASSIUM CHANNEL OPENERS COMPRISING GUANIDINE AND USES THEREOF | SALZMAN GROUP LTD. (IL) | 2021-03-11 | — | — | WO | disclosed |