Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23083834 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL29446660 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL29446699 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL29446686 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL23070766 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL23083660 | 0.93 | PTPN11 (0.59) | PTPN11KCNH2EGFR | |
| SCHEMBL23083743 | 0.93 | PTPN11 (0.59) | PTPN11KCNH2EGFR | |
| SCHEMBL23083792 | 0.93 | PTPN11 (0.59) | PTPN11KCNH2EGFR | |
| SCHEMBL23083744 | 0.93 | PTPN11 (0.58) | PTPN11KCNH2EGFR | |
| SCHEMBL23083675 | 0.93 | PTPN11 (0.58) | PTPN11KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127053-B | Substituted pyrazine compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-114127053-A | Substituted pyrazine compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2021043077-A1 | SUBSTITUTED PYRAZINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021043077-A1 | SUBSTITUTED PYRAZINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-03-11 | — | — | WO | disclosed |