SCHEMBL23073192

SCHEMBL23073192

CCc1nn(Cc2ccccc2)c2cc(-c3cc(C)c(=O)n(C)c3)cc(NS(=O)(=O)CC)c12

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 18/20 0.63
CREBBP Q92793 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18152698 0.90 BRD4 (0.63) BRD4CREBBP
SCHEMBL18152634 0.82 BRD4 (0.54) BRD4CREBBP
SCHEMBL18152792 0.82 BRD4 (0.65) BRD4CREBBP
SCHEMBL18152901 0.82 BRD4 (0.65) BRD4CREBBP
SCHEMBL18152749 0.81 BRD4 (0.53) BRD4
SCHEMBL18164204 0.79 BRD4 (0.51) BRD4
SCHEMBL18164345 0.78 BRD4 (0.51) BRD4CREBBP
SCHEMBL18528948 0.78 BRD4 (0.60) BRD4CREBBP
SCHEMBL18164326 0.76 CREBBP (0.55) BRD4CREBBP
SCHEMBL23072953 0.75 BRD4 (0.49) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283077-B1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RES INC (US) 2021-03-10 EP disclosed