Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14128270 | 0.94 | PARP1 (0.68) | PARP1 | |
| SCHEMBL14128267 | 0.94 | PARP1 (0.68) | PARP1 | |
| SCHEMBL29393790 | 0.94 | PARP1 (0.68) | PARP1 | |
| SCHEMBL24246331 | 0.94 | PARP1 (0.68) | PARP1 | |
| SCHEMBL14128269 | 0.86 | PARP1 (0.57) | PARP1 | |
| SCHEMBL29392975 | 0.82 | PARP1 (0.81) | PARP1HDAC1HDAC6PARP2 | |
| SCHEMBL14233512 | 0.82 | PARP1 (0.81) | PARP1HDAC1HDAC6PARP2 | |
| SCHEMBL23064712 | 0.81 | PARP1 (0.78) | PARP1 | |
| SCHEMBL24246330 | 0.78 | PARP1 (0.86) | PARP1 | |
| SCHEMBL23073370 | 0.78 | PARP1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714703-B1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | NEWGEN THERAPEUTICS INC (US) | 2021-03-10 | — | — | EP | disclosed |