SCHEMBL23079142

SCHEMBL23079142

BC(=O)c1cccc(C#N)c1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.61
GRM5 P41594 1/20 0.48
CLK1 P49759 1/20 0.46
DYRK1A Q13627 1/20 0.46
DYRK1B Q9Y463 1/20 0.46
ENPP2 Q13822 1/20 0.46
P4HB P07237 3/20 0.45
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
KMT2A Q03164 1/20 0.45
VNN1 O95497 3/20 0.44
IRAK4 Q9NWZ3 1/20 0.44
KAT6A Q92794 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
ELANE P08246 1/20 0.43
XDH P47989 1/20 0.42
SLC22A12 Q96S37 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2041048 0.84 GSK3B (0.61) GSK3BGRM5CLK1DYRK1ADYRK1B
SCHEMBL171168 0.84 GSK3B (0.61) GSK3BGRM5CLK1DYRK1ADYRK1B
Hydrochloric Acid SCHEMBL4380330 0.82 GSK3B (0.59) GSK3BGRM5MAPTVNN1
SCHEMBL60691 0.82 GSK3B (0.62) GSK3BGRM5XDHSLC22A12
SCHEMBL29441888 0.82 GSK3B (0.62) GSK3BGRM5XDHSLC22A12
SCHEMBL2164429 0.82 GSK3B (0.62) GSK3BGRM5CLK1DYRK1ADYRK1B
Water SCHEMBL2507779 0.81 GSK3B (0.57) GSK3BGRM5VNN1CLK4ELANE
Hydrochloric Acid SCHEMBL2031438 0.80 GSK3B (0.61) GSK3BGRM5XDHSLC22A12
SCHEMBL39137 0.80 GSK3B (0.61) GSK3BGRM5CLK1DYRK1ADYRK1B
SCHEMBL4169583 0.80 GSK3B (0.61) GSK3BGRM5CLK1DYRK1ADYRK1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021045879-A1 SYNTHESIS OF DEUTERATED ALDEHYDES ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2021-03-11 WO disclosed