Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.58 |
| ▸ | JAK2 | O60674 | 8/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2306022 | 0.91 | CHEK1 (0.59) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2303684 | 0.89 | JAK2 (0.59) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2307559 | 0.87 | JAK2 (0.57) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2306846 | 0.85 | JAK2 (0.55) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2307514 | 0.85 | JAK2 (0.62) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2303468 | 0.85 | JAK2 (0.52) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2304988 | 0.84 | JAK2 (0.57) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2304688 | 0.84 | JAK2 (0.54) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL3307769 | 0.84 | JAK2 (0.53) | CHEK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2304977 | 0.84 | JAK2 (0.56) | CHEK1JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042655-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Holdings Corporation (US) | 2016-07-13 | — | — | EP | disclosed |
| EP-2349260-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |