Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 11/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081059 | 0.90 | JAK3 (0.48) | JAK3BTKLCKEGFRSYK | |
| SCHEMBL23081060 | 0.89 | JAK3 (0.46) | JAK3BTKLCKEGFRMAP4K1 | |
| SCHEMBL18283696 | 0.89 | JAK3 (0.53) | JAK3BTKLCKEGFR | |
| SCHEMBL18283704 | 0.85 | JAK3 (0.54) | JAK3BTKLCKEGFRMAP4K1 | |
| SCHEMBL23080595 | 0.83 | BTK (0.45) | JAK3BTKLCKEGFRMAP4K1 | |
| SCHEMBL18283662 | 0.83 | JAK3 (0.55) | JAK3BTKLCKEGFRSYK | |
| SCHEMBL18296320 | 0.82 | JAK3 (0.43) | JAK3BTKLCKEGFRSYK | |
| SCHEMBL18283835 | 0.82 | BTK (0.56) | JAK3BTKLCKEGFRMAP4K1 | |
| SCHEMBL23080696 | 0.82 | JAK3 (0.45) | JAK3BTKLCKEGFRSYK | |
| SCHEMBL23080607 | 0.81 | JAK3 (0.45) | JAK3BTKLCKEGFRMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | JAK3 64/4885BTK 1/4885LCK 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.