Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.45 |
| ▸ | LCK | P06239 | 11/20 | 0.45 |
| ▸ | JAK3 | P52333 | 9/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080646 | 0.88 | JAK3 (0.54) | BTKLCKJAK3EGFR | |
| SCHEMBL23080996 | 0.87 | BTK (0.45) | BTKLCKJAK3EGFR | |
| SCHEMBL23080698 | 0.87 | BTK (0.61) | BTKLCKJAK3EGFR | |
| SCHEMBL18283957 | 0.81 | BTK (0.52) | BTKLCKJAK3EGFR | |
| SCHEMBL23080679 | 0.80 | JAK3 (0.39) | BTKLCKJAK3EGFR | |
| SCHEMBL23080677 | 0.79 | JAK3 (0.50) | BTKLCKJAK3EGFR | |
| SCHEMBL18283986 | 0.79 | JAK3 (0.56) | BTKLCKJAK3EGFR | |
| SCHEMBL18283703 | 0.79 | JAK3 (0.56) | BTKLCKJAK3EGFR | |
| SCHEMBL20539873 | 0.79 | JAK3 (0.56) | BTKLCKJAK3EGFR | |
| SCHEMBL18283741 | 0.79 | JAK3 (0.56) | BTKLCKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | BTK 1/4885LCK 3/4885JAK3 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.