Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.75 |
| ▸ | LCK | P06239 | 9/20 | 0.75 |
| ▸ | BTK | Q06187 | 11/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080981 | 0.89 | JAK3 (0.84) | JAK3LCKBTKEGFR | |
| SCHEMBL18283799 | 0.87 | JAK3 (0.57) | JAK3LCKBTKEGFR | |
| SCHEMBL16763896 | 0.86 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL16764241 | 0.86 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL23081038 | 0.85 | JAK3 (0.90) | JAK3LCKBTKEGFR | |
| SCHEMBL23081168 | 0.85 | JAK3 (0.73) | JAK3LCKBTKEGFR | |
| SCHEMBL23081127 | 0.84 | JAK3 (0.81) | JAK3LCKBTKEGFR | |
| SCHEMBL23081056 | 0.83 | JAK3 (0.81) | JAK3LCKBTKEGFR | |
| SCHEMBL23080791 | 0.82 | JAK3 (0.69) | JAK3LCKBTKEGFR | |
| SCHEMBL23081014 | 0.82 | JAK3 (0.80) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | JAK3 64/4885LCK 3/4885BTK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.