Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31160526 | 1.00 | GAA (0.44) | GAAABL1HPGDNR4A2MAPT | |
| SCHEMBL23118250 | 0.87 | GAA (0.45) | GAAABL1NR4A2MAPTALDH1A1 | |
| SCHEMBL3489830 | 0.84 | GAA (0.42) | GAAABL1HPGDNR4A2ALDH1A1 | |
| SCHEMBL935778 | 0.83 | HSD17B10 (0.49) | GAANR4A2MAPTALDH1A1NOTUM | |
| SCHEMBL14341400 | 0.83 | ABL1 (0.47) | GAAABL1HPGDNR4A2MAPT | |
| SCHEMBL1229320 | 0.83 | KDM4E (0.43) | GAANR4A2MAPTALDH1A1NOTUM | |
| SCHEMBL4831667 | 0.82 | GALK1 (0.49) | GAAABL1HPGDMAPTALDH1A1 | |
| SCHEMBL24792656 | 0.82 | GAA (0.49) | GAAABL1HPGDMAPTALDH1A1 | |
| SCHEMBL22492252 | 0.82 | SOS1 (0.43) | GAAABL1HPGDNR4A2MAPT | |
| SCHEMBL23714914 | 0.81 | CA12 (0.46) | GAAHPGDNR4A2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709718-A1 | 6-SUBSTITUTED-3-PHENYL-ISOINDOLIN-1-ONES AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | Genentech Inc. (US) | 2026-03-18 | — | — | EP | disclosed |
| US-12209091-B2 | Isoindolinone derivatives as selective allosteric inhibitors of Egfr mutant cancers | HOFFMANN-LA ROCHE INC. (US) | 2025-01-28 | — | — | US | disclosed |
| CN-115151538-A | Macrocyclic compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-10-04 | — | — | CN | disclosed |
| US-20210079005-A1 | COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2021-03-18 | — | — | US | disclosed |
| CN-112437774-A | Compound (I) | 豪夫迈·罗氏有限公司 | 2021-03-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12209091-B2 | Isoindolinone derivatives as selective allosteric inhibitors of Egfr mutant cancers | EGFR, ERBB2, ERBB3 | GAA 3754/4885ABL1 4/4885HPGD 3999/4885 |
| US-20210079005-A1 | COMPOUNDS | EGFR, ERBB2, ERBB3 | GAA 1670/4885ABL1 4/4885HPGD 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.