⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24619030 | 1.00 | — | — | |
| SCHEMBL16933713 | 1.00 | — | — | |
| SCHEMBL9475809 | 0.79 | LSS (0.31) | — | |
| SCHEMBL25125857 | 0.75 | — | — | |
| SCHEMBL3261312 | 0.75 | — | — | |
| SCHEMBL3261311 | 0.75 | — | — | |
| SCHEMBL8521327 | 0.73 | — | — | |
| SCHEMBL10918903 | 0.73 | TSHR (0.35) | — | |
| SCHEMBL15256355 | 0.73 | — | — | |
| SCHEMBL10918906 | 0.73 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359542-B1 | SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-17 | — | — | EP | disclosed |