Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 17/20 | 1.00 |
| ▸ | DRD2 | P14416 | 13/20 | 1.00 |
| ▸ | DRD3 | P35462 | 9/20 | 1.00 |
| ▸ | DRD5 | P21918 | 5/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.91 |
| ▸ | DRD4 | P21917 | 2/20 | 0.91 |
| ▸ | F3 | P13726 | 5/20 | 0.89 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.87 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.87 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | HTR1A | P08908 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CASP1 | P29466 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | APAF1 | O14727 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29999180 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL2742469 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL21192511 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL16035972 | 0.95 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL14703846 | 0.95 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL680031 | 0.95 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL29561422 | 0.95 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL13334113 | 0.94 | DRD1 (1.00) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| Hydrochloric Acid SCHEMBL3321082 | 0.93 | DRD1 (0.98) | DRD1DRD2DRD3DRD5SIGMAR1 | |
| SCHEMBL2742673 | 0.91 | DRD1 (0.85) | DRD1DRD2DRD3DRD5SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230172916-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME | ELEONOR (BE) | 2023-06-08 | — | — | US | claimed |
| EP-4135666-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME | Eleonor (BE) | 2023-02-22 | — | — | EP | claimed |
| WO-2021209623-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME | ELEONOR SPRL (BE) | 2021-10-21 | — | — | WO | claimed |
| EP-3672575-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND ITS PRODUCTION PROCESS | Eleonor SPRL (BE) | 2020-07-01 | — | — | EP | claimed |
| WO-2019038430-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND ITS PRODUCTION PROCESS | ELEONOR SPRL (BE) | 2019-02-28 | — | — | WO | claimed |
| CN-107260737-A | The medicinal usage of corypalmine | 上海华堇生物技术有限责任公司 | 2017-10-20 | — | — | CN | claimed |
| EP-2983473-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS Mountain Llc (US) | 2016-02-17 | — | — | EP | claimed |
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| WO-2014144130-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC (US) | 2014-09-18 | — | — | WO | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| EP-1265485-A1 | USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES | Leis, Michelangelo (IT) | 2002-12-18 | — | — | EP | claimed |
| WO-2001062089-A1 | USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES | LEIS MICHELANGELO (IT) | 2001-08-30 | — | — | WO | claimed |
| CN-119157878-A | Application of tetrahydrojatrorrhizine in preparation of medicine for treating rheumatoid arthritis | 北京大学 | 2024-12-20 | — | — | CN | disclosed |
| CN-118304302-A | Application of hairyvein agrimony alkali or isomer rupestrine thereof in preparing medicament for treating human blood malignant tumor | 南京中医药大学 | 2024-07-09 | — | — | CN | disclosed |
| CN-117379379-A | Alkaloid compound-containing nano-particles and application thereof in medicines for treating osteoarthritis | 新乡医学院 | 2024-01-12 | — | — | CN | disclosed |
| US-20230398166-A1 | METHOD FOR EXTRACTING A FULL SPECTRUM OF HYDROPHILIC COMPOUNDS FROM BIOMASS | TUDELA JERRED (US) | 2023-12-14 | — | — | US | disclosed |
| EP-1265485-A1 | USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES | Leis, Michelangelo (IT) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001062089-A1 | USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES | LEIS MICHELANGELO (IT) | 2001-08-30 | — | — | WO | disclosed |
| US-5242926-A | Therapeutic composition for treating hyperthyroidism | NATIONAL SCIENCE COUNCIL OF REPUBLIC OF CHINA (TW) | 1993-09-07 | — | — | US | disclosed |
| US-4657861-A | S-tetrahydroprotoberberineoxidase, process for producing the same and use thereof | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1987-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230172916-A1 | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME | MANBA, CROCC, MAN2A1 | DRD1 1370/4885DRD2 1092/4885DRD3 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.