Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28633359 | 0.98 | PAOX (0.42) | PAOXSIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL8071370 | 0.92 | PAOX (0.39) | PAOXSIGMAR1USP2ALDH1A1HPGD | |
| SCHEMBL28642601 | 0.84 | PAOX (0.33) | PAOXSIGMAR1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8116181 | 0.80 | PAOX (0.50) | PAOXSIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL24752794 | 0.80 | PAOX (0.50) | PAOXSIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL9276057 | 0.79 | CACNA2D1 (0.43) | HRH3TP53SMN1; SMN2 | |
| SCHEMBL22790763 | 0.79 | CACNA2D1 (0.47) | HRH3SMN1; SMN2 | |
| SCHEMBL105381 | 0.78 | PAOX (0.47) | PAOXSIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL26352150 | 0.77 | HRH3 (0.48) | HRH3SMN1; SMN2 | |
| SCHEMBL31632718 | 0.77 | PAOX (0.64) | PAOXSIGMAR1GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050702-A1 | KDM INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |