Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 7/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.50 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.50 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.50 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23105207 | 1.00 | KRAS (0.50) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092614 | 0.87 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105086 | 0.86 | KRAS (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL24851564 | 0.86 | KRAS (0.48) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105233 | 0.85 | KRAS (0.51) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092294 | 0.83 | KRAS (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105193 | 0.82 | KRAS (0.64) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105132 | 0.80 | KRAS (0.70) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092291 | 0.80 | KRAS (0.69) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092322 | 0.79 | KRAS (0.58) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021051034-A1 | RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2021-03-18 | — | — | WO | disclosed |