Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.65 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.64 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.64 |
| ▸ | TNF | P01375 | 3/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.64 |
| ▸ | IL1B | P01584 | 1/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.64 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.60 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22000908 | 0.91 | CRBN (0.73) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL22000913 | 0.89 | CRBN (0.70) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL24132344 | 0.89 | CRBN (0.61) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL24850603 | 0.89 | CRBN (0.61) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL22000911 | 0.88 | CRBN (0.69) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL19586849 | 0.87 | CRBN (0.67) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL19586041 | 0.86 | CRBN (0.64) | CRBNIKZF3IKZF1TNFBRD4 | |
| Hydrochloric Acid SCHEMBL31753181 | 0.86 | CRBN (0.66) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL22511592 | 0.85 | CRBN (0.69) | CRBNIKZF3IKZF1TNFBRD4 | |
| SCHEMBL30805461 | 0.85 | CRBN (0.60) | CRBNIKZF3IKZF1TNFBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266206-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| WO-2021051034-A1 | RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2021-03-18 | — | — | WO | disclosed |