SCHEMBL23112701

SCHEMBL23112701

NC(c1ccc(F)cc1)C(F)(F)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 7/20 0.40
DPP7 Q9UHL4 5/20 0.40
DPP9 Q86TI2 3/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
KCNN4 O15554 3/20 0.38
DPP8 Q6V1X1 3/20 0.38
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23112700 1.00 DPP4 (0.40) DPP4DPP7DPP9HDAC3HDAC4
Hydrochloric Acid SCHEMBL23112467 0.98 DPP4 (0.39) DPP4DPP7DPP9HDAC3HDAC4
Hydrochloric Acid SCHEMBL23112468 0.98 DPP4 (0.39) DPP4DPP7DPP9HDAC3HDAC4
SCHEMBL288096 0.84 CYP2D6 (0.41) DPP4
SCHEMBL17841494 0.84 CYP2D6 (0.41) DPP4
Hydrochloric Acid SCHEMBL7834229 0.79 DPP4 (0.39) DPP4DPP7DPP9HDAC3HDAC4
SCHEMBL29009847 0.78 HDAC3 (0.41) DPP4DPP7DPP9HDAC3HDAC4
SCHEMBL24361184 0.78 HDAC3 (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2
Trifluoroacetic Acid SCHEMBL9299736 0.77 DPP4 (0.47) DPP4DPP7DPP9DPP8KCNH2
SCHEMBL23377838 0.75 MAPT (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021094208-A1 SUBSTITUTED IMIDAZO PYRIMIDINE EP3 ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2021-05-20 WO disclosed
WO-2021094210-A1 SUBSTITUTED PYRAZINE CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN EP3 RECEPTOR ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2021-05-20 WO disclosed
WO-2021094209-A1 SUBSTITUTED PYRROLO TRIAZINE CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN EP3 RECEPTOR ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2021-05-20 WO disclosed
EP-3793559-A1 SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES Bayer Aktiengesellschaft (DE) 2021-03-24 EP disclosed