Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.50 |
| ▸ | GSPT1 | P15170 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23119749 | 0.88 | MAOB (0.43) | CRBNDDB1GSPT1RAB9ANPC1 | |
| SCHEMBL23119720 | 0.86 | RXFP1 (0.47) | RAB9ANPC1TP53MAPTSMN1; SMN2 | |
| SCHEMBL23119753 | 0.84 | CRBN (0.49) | CRBNDDB1RAB9ANPC1CASP3 | |
| SCHEMBL23119853 | 0.83 | CRBN (0.49) | CRBNDDB1GSPT1RAB9ANPC1 | |
| SCHEMBL26728488 | 0.83 | NPC1 (0.41) | CRBNDDB1RAB9ANPC1CASP3 | |
| SCHEMBL31356205 | 0.81 | TNF (0.46) | CRBNDDB1RAB9APOLBKMT2A | |
| SCHEMBL23117764 | 0.81 | DDB1 (0.48) | CRBNDDB1GSPT1 | |
| SCHEMBL23115191 | 0.81 | DDB1 (0.56) | CRBNDDB1GSPT1MEN1KMT2A | |
| SCHEMBL26728512 | 0.80 | MAPKAPK2 (0.43) | CRBNDDB1RAB9ANPC1CSNK1A1 | |
| SCHEMBL23119831 | 0.80 | CRBN (0.41) | CRBNDDB1GSPT1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021047627-A1 | FUSED CYCLIC COMPOUND CAPABLE OF DEGRADING PROTEIN AND USE THEREOF | 南京明德新药研发有限公司 | 2021-03-18 | — | — | WO | disclosed |