Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 19/20 | 0.54 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 0.54 |
| ▸ | TAF1 | P21675 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.54 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.54 |
| ▸ | BPTF | Q12830 | 1/20 | 0.54 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.54 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.54 |
| ▸ | ATAD2B | Q9ULI0 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | VHL | P40337 | 1/20 | 0.43 |
| ▸ | ELOC | Q15369 | 1/20 | 0.43 |
| ▸ | ELOB | Q15370 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25933364 | 0.95 | BRD9 (0.49) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL22291253 | 0.93 | BRD9 (0.58) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL30297128 | 0.92 | BRD9 (0.56) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23122723 | 0.91 | BRD9 (0.54) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL33532942 | 0.90 | BRD9 (0.54) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23121776 | 0.88 | BRD9 (0.49) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL30297135 | 0.88 | BRD9 (0.52) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL25933271 | 0.88 | BRD9 (0.54) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23123264 | 0.87 | BRD9 (0.52) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23125025 | 0.87 | BRD9 (0.55) | BRD9BRD7TAF1TGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220315578-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-10-06 | — | — | US | disclosed |
| EP-4041724-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |
| CN-114641473-A | BRD9 bifunctional degradation agent and use method thereof | 诺华股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315578-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | BRD9, BRD2, BRD1 | BRD9 1/4885BRD7 5/4885TAF1 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.