Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 14/20 | 0.71 |
| ▸ | RANBP1 | P43487 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23133420 | 1.00 | XPO1 (0.71) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17790542 | 0.93 | XPO1 (0.82) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16325038 | 0.93 | XPO1 (0.82) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16322954 | 0.93 | XPO1 (0.82) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL23133415 | 0.91 | XPO1 (0.86) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL23133144 | 0.91 | XPO1 (0.86) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17788771 | 0.88 | XPO1 (0.71) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17788770 | 0.88 | XPO1 (0.71) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17788772 | 0.88 | XPO1 (0.71) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL23116715 | 0.87 | XPO1 (0.70) | XPO1RANBP1KCNH2ESR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303530-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XWPharma Ltd. (KY) | 2023-09-28 | — | — | US | disclosed |
| US-11767313-B2 | Compounds as nuclear transport modulators and uses thereof | XWPharma Ltd. (KY) | 2023-09-26 | — | — | US | disclosed |
| US-20210087177-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XWPharma Ltd. (KY) | 2021-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767313-B2 | Compounds as nuclear transport modulators and uses thereof | XPOT, XPO1, XPO5 | XPO1 2/4885RANBP1 131/4885KCNH2 4220/4885 |
| US-20230303530-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPOT, XPO1, XPO5 | XPO1 2/4885RANBP1 131/4885KCNH2 4220/4885 |
| US-20210087177-A1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPOT, XPO1, XPO5 | XPO1 2/4885RANBP1 131/4885KCNH2 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.