Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 8/20 | 0.70 |
| ▸ | CTSG | P08311 | 3/20 | 0.70 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2310961 | 0.99 | CMA1 (0.69) | CMA1CTSGCRHR1CRHR2MEN1 | |
| SCHEMBL2309114 | 0.83 | CMA1 (1.00) | CMA1CTSGALDH1A1 | |
| SCHEMBL2310618 | 0.81 | CMA1 (0.69) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2312717 | 0.80 | CMA1 (0.74) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2310958 | 0.80 | CMA1 (0.68) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2310016 | 0.79 | CMA1 (0.72) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2310315 | 0.79 | CMA1 (0.72) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2308648 | 0.78 | CMA1 (0.69) | CMA1CTSGMEN1ALDH1A1KMT2A | |
| SCHEMBL2312364 | 0.76 | CMA1 (0.67) | CMA1CTSGCRHR2LMNASMN1; SMN2 | |
| SCHEMBL2805710 | 0.76 | CMA1 (0.69) | CMA1CTSGMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | claimed |