Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | RAF1 | P04049 | 5/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312412 | 0.80 | TP53 (0.67) | MAPTRAF1BRAFSMN1; SMN2TP53 | |
| SCHEMBL4829508 | 0.80 | CSF1R (0.68) | RAF1BRAFCSF1R | |
| SCHEMBL15937435 | 0.79 | JAK3 (0.44) | MAPTRAF1BRAFSMN1; SMN2MAPK1 | |
| SCHEMBL18394518 | 0.79 | PRKDC (0.48) | MAPTLMNAL3MBTL1 | |
| SCHEMBL5897175 | 0.78 | MAPK14 (0.59) | MAPTRAF1BRAFSMN1; SMN2MAPK1 | |
| SCHEMBL28870257 | 0.78 | SMN1; SMN2 (0.69) | MAPTRAF1BRAFSMN1; SMN2TP53 | |
| SCHEMBL4827472 | 0.76 | RAF1 (0.64) | RAF1BRAFMAPK1TP53NPC1 | |
| SCHEMBL1408452 | 0.76 | PTGS1 (0.66) | SMN1; SMN2ALDH1A1LMNACYP1A2 | |
| SCHEMBL15924738 | 0.75 | PRKDC (0.54) | MAPTL3MBTL1 | |
| SCHEMBL4250568 | 0.74 | KIT (0.61) | RAF1BRAFMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |