SCHEMBL2313650

SCHEMBL2313650

ONCc1cccnc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5549240 0.98 CYP1A2 (0.67)
Hydrochloric Acid SCHEMBL3555281 0.98 CYP1A2 (0.67)
SCHEMBL5361875 0.82 CYP1A2 (0.75)
SCHEMBL2861457 0.82 CYP1A2 (1.00)
Hydrochloric Acid SCHEMBL8725767 0.82 CYP1A2 (0.62)
Hydrochloric Acid SCHEMBL6121350 0.80 CYP1A2 (0.95)
SCHEMBL10054984 0.78 CYP1A2 (0.91)
SCHEMBL14825004 0.78
SCHEMBL19031318 0.78 CYP1A2 (0.83)
SCHEMBL1629085 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3907221-A1 FLUORINE-CONTAINING SUBSTITUTED BENZOTHIOPHENE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2021-11-10 EP disclosed
WO-2020140894-A1 FLUORINE-CONTAINING SUBSTITUTED BENZOTHIOPHENE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 中国科学院上海药物研究所 2020-07-09 WO disclosed
EP-2057166-B1 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF (3-ALKYL-5-PIPERIDIN-1-YL-3,3A-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-AMINO DERIVATIVES MERCK SHARP & DOHME (US) 2018-07-11 EP disclosed
US-8076479-B2 useful as cyclin-dependent kinase inhibitor compounds; minimizes the need for chromatographic purification of intermediates, and utilizes fewer changes of solvent systems SCHERING CORPORATION (US) 2011-12-13 US disclosed
WO-2011121068-A1 AMINO DERIVATIVES OF CYCLOHEX-2-ENONE, THEIR PREPARATION AND USE AS ANTIOXIDANTS ABIOGEN PHARMA S.P.A. (IT) 2011-10-06 WO disclosed
EP-2371816-A1 Aminocyclohexenone, their preparation and use as medicament against oxidative stress ABIOGEN PHARMA S.p.A. (IT) 2011-10-05 EP disclosed
EP-1888579-B1 NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF AVENTIS PHARMA SA (FR) 2011-08-03 EP disclosed
EP-2057166-A2 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF (3-ALKYL-5-PIPERIDIN-1-YL-3,3A-DIHYDRO- PYRAZOLOÝ1,5-A¨PYRIMIDIN-7-YL)-AMINO DERIVATIVES AND INTERMEDIATES SCHERING CORPORATION (US) 2009-05-13 EP disclosed
WO-2008027220-A2 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF (3-ALKYL-5-PIPERIDIN-1-YL-3, 3A-DIHYDROPYRAZOL0 [1, 5-A] PYRIMIDIN-7-YL) -AMINO DERIVATIVES SCHERING CORPORATION (US) 2008-03-06 WO disclosed
US-20080058518-A1 Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates MERCK SHARP & DOHME LLC 2008-03-06 US disclosed
EP-1888579-A2 NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF Aventis Pharma S.A. (FR) 2008-02-20 EP disclosed
WO-2006123061-A2 FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF AVENTIS PHARMA S.A. (FR) 2006-11-23 WO disclosed