⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293807 | 0.81 | — | — | |
| SCHEMBL6178735 | 0.73 | TDP1 (0.32) | — | |
| SCHEMBL10695655 | 0.72 | — | — | |
| SCHEMBL3196903 | 0.71 | TDP1 (0.31) | — | |
| SCHEMBL937940 | 0.71 | TDP1 (0.31) | — | |
| SCHEMBL3327598 | 0.71 | TDP1 (0.31) | — | |
| SCHEMBL6006558 | 0.69 | TDP1 (0.31) | — | |
| SCHEMBL5662995 | 0.69 | CYP2D6 (0.35) | — | |
| SCHEMBL21293786 | 0.68 | — | — | |
| SCHEMBL567668 | 0.68 | TDP1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12157726-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | SHANGHAI ZHIMENG BIOPHARMA INC. | 2024-12-03 | — | — | US | disclosed |
| EP-3798220-B1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC (CN) | 2023-08-23 | — | — | EP | disclosed |
| CN-113372345-B | Deuterated heterocyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2022-08-16 | — | — | CN | disclosed |
| US-20220227721-A1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2022-07-21 | — | — | US | disclosed |
| US-11365181-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2022-06-21 | — | — | US | disclosed |
| CN-112574211-B | Heterocyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-112574179-B | DNA-PK inhibitors | 山东轩竹医药科技有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-110511220-B | P-diaminobenzene derivatives as potassium channel modulators, process for their preparation and their use in medicine | 上海挚盟医药科技有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-113372345-A | Deuterated heterocyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2021-09-10 | — | — | CN | disclosed |
| US-20210163429-A1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2021-06-03 | — | — | US | disclosed |
| EP-3798220-A1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | Shanghai Zhimeng Biopharma, Inc. (CN) | 2021-03-31 | — | — | EP | disclosed |
| CN-112574179-A | DNA-PK inhibitors | 山东轩竹医药科技有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112574211-A | Heterocyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112119079-A | P-diaminobenzene derivatives as potassium channel modulators, process for their preparation and their use in medicine | 上海挚盟医药科技有限公司 | 2020-12-22 | — | — | CN | disclosed |