7-Oxocholesterol

7-Oxocholesterol

SCHEMBL231536

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C=C4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1L1 Q9UHC9 6/20 1.00
RORA P35398 3/20 1.00
USP2 O75604 3/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
ALOX15 P16050 1/20 1.00
NR1H3 Q13133 2/20 0.73
RORC P51449 4/20 0.67
GPR183 P32249 4/20 0.67
OSBP P22059 3/20 0.67
LMNA P02545 2/20 0.67
ABCB1 P08183 1/20 0.67
OSBP2 Q969R2 1/20 0.67
CYP46A1 Q9Y6A2 1/20 0.67
GABRA1 P14867 1/20 0.65
GABRB1 P18505 1/20 0.65
GABRG2 P18507 1/20 0.65
GABRB3 P28472 1/20 0.65
GABRA5 P31644 1/20 0.65
GABRA3 P34903 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
7-Oxocholesterol SCHEMBL19866342 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL19545218 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL19545521 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL19858756 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL14629361 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL231535 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL23062985 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL6389039 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL2600410 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A
7-Oxocholesterol SCHEMBL22959498 1.00 NPC1L1 (1.00) NPC1L1RORAUSP2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055615-A Method for diagnosing exposure of skin to ozone 欧莱雅 2026-05-15 CN claimed
WO-2026090423-A1 UNIVERSAL LNP COMPOSITIONS PRIME MEDICINE, INC (US) 2026-04-30 WO claimed
EP-4706644-A1 RECONSTITUTED HIGH-DENSITY LIPOPROTEIN NANOPARTICLES COMPRISING CHOLESTEROL Mepsgen Co., Ltd. (KR) 2026-03-11 EP claimed
US-20250345358-A1 HYDROXYPROPYL BETA-CYCLODEXTRIN COMPOSITIONS AND METHODS MANDOS LLC (US) 2025-11-13 US claimed
US-20250345284-A1 LIPID NANOPARTICLE (LNP) COMPOSITIONS AND METHODS OF USE THEREOF THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2025-11-13 US claimed
US-20250326839-A1 TREATMENT OF DISEASES RELATED TO COLONY-STIMULATING FACTOR 1 RECEPTOR DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE INC (US) 2025-10-23 US claimed
US-20250282866-A1 TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE INC (US) 2025-09-11 US claimed
WO-2025132799-A1 METHODS FOR DIAGNOSIS AND MONITORING NASH DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2025-06-26 WO claimed
CN-120084899-A HPLC analysis method capable of simultaneously controlling two different 7-dehydrocholesterol synthesis routes 苏州恩泰新材料科技有限公司 2025-06-03 CN claimed
WO-2025073784-A1 METHOD FOR DIAGNOSING A SKIN EXPOSED TO OZONE L'OREAL (FR) 2025-04-10 WO claimed
US-20030139616-A1 Method of searching for arteriosclerosis inhibitors and shrinkers TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2003-07-24 US claimed
WO-2001015676-A9 COMPOSITIONS AND METHODS FOR MODULATING HDL CHOLESTEROL AND TRIGLYCERIDE LEVELS UNIV BRITISH COLUMBIA (CA) 2003-06-19 WO claimed
WO-2003049685-A2 TREATMENT FOR AGE-RELATED MACULAR DEGENERATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2003-06-19 WO claimed
EP-1277760-A1 METHOD OF SEARCHING FOR ARTERIOSCLEROSIS INHIBITORS AND SHRINKERS Takeda Chemical Industries, Ltd. (JP) 2003-01-22 EP claimed
EP-1239848-A2 COMPOSITIONS AND METHODS FOR MODULATING HDL CHOLESTEROL AND TRIGLYCERIDE LEVELS University of British Columbia (CA) 2002-09-18 EP claimed
WO-2002043742-A1 CYCLODEXTRINS AND REVERSAL OF ATHEROSCLEROSIS THE HEART RESEARCH INSTITUTE LTD (AU) 2002-06-06 WO claimed
WO-2001015676-A2 COMPOSITIONS AND METHODS FOR MODULATING HDL CHOLESTEROL AND TRIGLYCERIDE LEVELS UNIVERSITY OF BRITISH COLUMBIA (CA) 2001-03-08 WO claimed
WO-1999024400-A1 PROBUCOL ESTERS AND USES THEREOF VYREX CORPORATION (US) 1999-05-20 WO claimed
US-4304726-A REDUCING 7-KETOCHOLESTEROL HALFESTER WITH COMPLEX METAL HYDRIDE THE GREEN CROSS CORPORATION (JP) 1981-12-08 US claimed
US-4157391-A IMMUNOREGULATORY AGENTS OR ANTIPHLOGISTIC AGENTS THE GREEN CROSS CORPORATION (JP) 1979-06-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250345284-A1 LIPID NANOPARTICLE (LNP) COMPOSITIONS AND METHODS OF USE THEREOF CD47, CETP, HAVCR2 NPC1L1 18/4885RORA 26/4885USP2 4200/4885
US-20250345358-A1 HYDROXYPROPYL BETA-CYCLODEXTRIN COMPOSITIONS AND METHODS GBA1, NPC1, GBA2 NPC1L1 6/4885RORA 1463/4885USP2 1973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.