Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.45 |
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23156819 | 1.00 | KRAS (0.45) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21005734 | 0.93 | KRAS (0.47) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL23841834 | 0.88 | KRAS (0.41) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL24781614 | 0.88 | KRAS (0.52) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL23481644 | 0.86 | KRAS (0.45) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25021052 | 0.82 | KRAS (0.39) | KRASSOS1 | |
| SCHEMBL21908548 | 0.82 | KRAS (0.41) | KRAS | |
| SCHEMBL19964192 | 0.82 | KRAS (0.53) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25021516 | 0.82 | KRAS (0.39) | KRASSOS1 | |
| SCHEMBL19964061 | 0.82 | KRAS (0.53) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389021-A1 | INHIBITORS OF KRAS G12C | BEONE MEDICINES I GMBH (CH) | 2022-12-08 | — | — | US | disclosed |
| CN-114929706-A | Inhibitors of KRAS G12C | 百济神州有限公司 | 2022-08-19 | — | — | CN | disclosed |
| WO-2021058018-A1 | INHIBITORS OF KRAS G12C | BEIGENE, LTD. (KY) | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389021-A1 | INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | KRAS 1/4885VHL 10/4885CDK7 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.