Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.62 |
| ▸ | MTOR | P42345 | 17/20 | 0.62 |
| ▸ | PRKDC | P78527 | 15/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 14/20 | 0.60 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.60 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | HCK | P08631 | 12/20 | 0.58 |
| ▸ | KDR | P35968 | 12/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20553345 | 0.92 | MTOR (0.55) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL29669760 | 0.92 | MTOR (0.55) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7894790 | 0.89 | PIK3CD (0.64) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7902212 | 0.85 | MTOR (0.61) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7894935 | 0.85 | MTOR (0.64) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7900433 | 0.85 | IGF1R (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL23150471 | 0.84 | MTOR (0.58) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30405304 | 0.84 | MTOR (0.84) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21528175 | 0.84 | MTOR (0.84) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7906422 | 0.83 | SRC (0.67) | SRCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234031-A2 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| US-11685749-B2 | C26-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685749-B2 | C26-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2023-06-27 | — | — | US | disclosed |
| EP-3788049-B1 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20230055672-A1 | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-02-23 | — | — | US | disclosed |
| US-11364300-B2 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210338824-A1 | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2021-11-04 | — | — | US | disclosed |
| US-10980889-B1 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685749-B2 | C26-linked rapamycin analogs as mTOR inhibitors | MTOR, RICTOR, RPTOR | SRC 715/4885PIK3CD 142/4885PIK3CA 58/4885 |
| US-10980889-B1 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | MTOR, RICTOR, RPTOR | SRC 971/4885PIK3CD 94/4885PIK3CA 60/4885 |
| US-20210338824-A1 | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors | MTOR, RICTOR, RPTOR | SRC 971/4885PIK3CD 94/4885PIK3CA 60/4885 |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | KRAS, HRAS, MTOR | SRC 148/4885PIK3CD 215/4885PIK3CA 122/4885 |
| US-11364300-B2 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | MTOR, RICTOR, RPTOR | SRC 971/4885PIK3CD 94/4885PIK3CA 60/4885 |
| US-20230055672-A1 | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors | MTOR, RICTOR, RPTOR | SRC 971/4885PIK3CD 94/4885PIK3CA 60/4885 |
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | SRC 579/4885PIK3CD 117/4885PIK3CA 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.