Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17836532 | 0.92 | BRAF (0.45) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2312858 | 0.90 | BRAF (0.43) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2315402 | 0.90 | BRAF (0.43) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL14719024 | 0.89 | BRAF (0.41) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2360011 | 0.88 | BRAF (0.43) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2358053 | 0.87 | BRAF (0.41) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2316406 | 0.86 | BRAF (0.41) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2359732 | 0.86 | BRAF (0.41) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2313543 | 0.86 | BRAF (0.42) | BRAFNR1I2CDK2CDC7CCNE1 | |
| SCHEMBL2317507 | 0.85 | BRAF (0.39) | BRAFNR1I2CDK2CDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528909-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | claimed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | claimed |