Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.63 |
| ▸ | JAK2 | O60674 | 13/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.55 |
| ▸ | JAK3 | P52333 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22696706 | 0.86 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23168476 | 0.85 | JAK2 (0.51) | JAK1JAK2TYK2JAK3HDAC6 | |
| SCHEMBL23168421 | 0.85 | JAK1 (0.66) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL29467011 | 0.82 | JAK1 (0.64) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22638036 | 0.82 | JAK1 (0.64) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22648835 | 0.82 | JAK1 (0.64) | JAK1JAK2TYK2JAK3HDAC6 | |
| SCHEMBL22648676 | 0.80 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22686512 | 0.80 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22648763 | 0.80 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL28722824 | 0.80 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021062036-A1 | JAK INHIBITORS | VIMALAN BIOSCIENCES, INC. (US) | 2021-04-01 | — | — | WO | disclosed |