Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 0.91 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.91 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253643 | 1.00 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL233809 | 0.95 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL715472 | 0.95 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18840666 | 0.95 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL237559 | 0.93 | PDE5A (0.87) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7431010 | 0.93 | PDE5A (0.87) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL237558 | 0.93 | PDE5A (0.87) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL714981 | 0.92 | PDE5A (0.85) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL714980 | 0.92 | PDE5A (0.85) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL714979 | 0.92 | PDE5A (0.85) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400970-A1 | PDE 1 INHIBITORS FOR OPHTHALMIC DISORDERS | Intra-Cellular Therapies, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098839-A1 | PDE 1 INHIBITORS FOR OPHTHALMIC DISORDERS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| EP-2089034-A1 | NOVEL USES | Intra-Cellular Therapies, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-2081431-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008070095-A1 | NOVEL USES | INTRA-CELLULAR THERAPIES, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008063505-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2008-05-29 | — | — | WO | disclosed |