Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.32 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548921 | 1.00 | CHRNA7 (0.52) | CHRNA7ALDH1A1PSMB1PSMB8PSMB9 | |
| Hydrochloric Acid SCHEMBL10568351 | 0.98 | CHRNA7 (0.50) | CHRNA7ALDH1A1PSMB1PSMB8PSMB9 | |
| SCHEMBL2086631 | 0.98 | CHRNA7 (0.50) | CHRNA7ALDH1A1PSMB1PSMB8PSMB9 | |
| SCHEMBL4758959 | 0.98 | CHRNA7 (0.50) | CHRNA7ALDH1A1PSMB1PSMB8PSMB9 | |
| SCHEMBL4757799 | 0.98 | CHRNA7 (0.50) | CHRNA7ALDH1A1PSMB1PSMB8PSMB9 | |
| Hydrochloric Acid SCHEMBL26112499 | 0.85 | CHRNA7 (0.64) | CHRNA7ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL9091935 | 0.83 | — | — | |
| SCHEMBL16042687 | 0.81 | CHRNA7 (0.81) | CHRNA7ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL843660 | 0.72 | — | — | |
| SCHEMBL6099669 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094742-B1 | SUBSTITUTED AZABICYCLO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1990-08-01 | — | — | EP | claimed |
| US-4697019-A | Azabicyclo compounds, useful as intermediates | BEECHAM GROUP P.L.C. (GB) | 1987-09-29 | — | — | US | claimed |
| JP-5194513-A | — | — | None | — | — | JP | disclosed |
| US-9206181-B2 | 1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders | NOVARTIS AG (CH) | 2015-12-08 | — | — | US | disclosed |
| US-20140256940-A1 | 1-AZA-BICYCLO[3.3.1] NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS | NOVARTIS AG (CH) | 2014-09-11 | — | — | US | disclosed |
| US-8759346-B2 | Organic compounds | NOVARTIS AG (CH) | 2014-06-24 | — | — | US | disclosed |
| EP-1966208-B1 | (1-AZA-BICYCLO[3.3.1]NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-AChR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS | NOVARTIS AG (CH) | 2011-11-02 | — | — | EP | disclosed |
| EP-2354141-A1 | (1-aza-bicyclo[3.3.1]non-4-yl)-[5-(1h-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenrative disorders. | Novartis AG (CH) | 2011-08-10 | — | — | EP | disclosed |
| US-20100184775-A1 | ORGANIC COMPOUNDS | NOVARTIS AG | 2010-07-22 | — | — | US | disclosed |
| US-7713977-B2 | Drug for psychological and central nervous system disorders | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | disclosed |
| US-20080262030-A1 | Drug for psychological and central nervous system disorders | NOVARTIS AG (CH) | 2008-10-23 | — | — | US | disclosed |
| EP-0370283-A2 | Process for preparing 63-carboxyamides of teicoplanin antibiotics | GRUPPO LEPETIT S.p.A. (IT) | 1990-05-30 | — | — | EP | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4859683-A | Certain benzoxepins and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| US-4857647-A | 4-amino-5-chloro-2-methoxy-n-(6-(1-azabicyclo[3,2,1]octyl)benzamide | BEECHAM GROUP P.L.C. (GB) | 1989-08-15 | — | — | US | disclosed |
| US-4697019-A | Azabicyclo compounds, useful as intermediates | BEECHAM GROUP P.L.C. (GB) | 1987-09-29 | — | — | US | disclosed |
| EP-0218099-A2 | Amides of teicoplanin compounds | GRUPPO LEPETIT S.p.A. (IT) | 1987-04-15 | — | — | EP | disclosed |
| US-4612319-A | Bridged quinolizidinylbenzamides, compositions containing them and methods for their use | BEECHAM GROUP P.L.C. (GB) | 1986-09-16 | — | — | US | disclosed |
| EP-0094742-A2 | Substituted azabicyclo compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184775-A1 | ORGANIC COMPOUNDS | OTC, INA, SNCA | CHRNA7 138/4885ALDH1A1 611/4885PSMB1 2043/4885 |
| US-20080262030-A1 | Drug for psychological and central nervous system disorders | CNR1, CNR2, SLC6A2 | CHRNA7 36/4885ALDH1A1 2084/4885PSMB1 1777/4885 |
| US-20140256940-A1 | 1-AZA-BICYCLO[3.3.1] NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS | CHRNA5, CHRNA10, CHRNA7 | CHRNA7 3/4885ALDH1A1 1977/4885PSMB1 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.