Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 13/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17836533 | 0.90 | CSNK1D (0.47) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2316345 | 0.88 | BRAF (0.34) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL14108508 | 0.87 | CSNK1D (0.44) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2357435 | 0.87 | CSNK1D (0.44) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL14719344 | 0.85 | CSNK1D (0.41) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2359173 | 0.85 | CSNK1D (0.42) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2359967 | 0.83 | MAPK14 (0.40) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2359183 | 0.83 | CSNK1D (0.40) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2313575 | 0.83 | CSNK1D (0.40) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL14719347 | 0.82 | CSNK1D (0.38) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528909-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | claimed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | claimed |