Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 13/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BIRC3 | Q13489 | 5/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 5/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2318389 | 1.00 | XIAP (0.65) | XIAPHPGDTSHRKMT2ABIRC3 | |
| SCHEMBL2319796 | 0.94 | XIAP (0.67) | XIAPHPGDTSHRKMT2ABIRC3 | |
| SCHEMBL2319791 | 0.94 | XIAP (0.67) | XIAPHPGDTSHRKMT2ABIRC3 | |
| SCHEMBL2318949 | 0.91 | XIAP (0.56) | XIAPHPGDTSHRKMT2ADHODH | |
| SCHEMBL2318958 | 0.91 | XIAP (0.56) | XIAPHPGDTSHRKMT2ADHODH | |
| SCHEMBL2212223 | 0.89 | XIAP (0.61) | XIAPHPGDTSHRKMT2ABIRC3 | |
| SCHEMBL2211890 | 0.89 | XIAP (0.61) | XIAPHPGDTSHRKMT2ABIRC3 | |
| SCHEMBL2316174 | 0.88 | XIAP (0.53) | XIAPBIRC3BIRC2DHODH | |
| SCHEMBL2316166 | 0.88 | XIAP (0.53) | XIAPBIRC3BIRC2DHODH | |
| SCHEMBL2358625 | 0.87 | XIAP (0.57) | XIAPHPGDTSHRKMT2ABIRC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989441-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-02 | — | — | US | claimed |
| US-20090069294-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-03-12 | — | — | US | claimed |
| US-20110281845-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-17 | — | — | US | disclosed |
| US-20110281845-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-17 | — | — | US | disclosed |
| US-7989441-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-02 | — | — | US | disclosed |
| US-7989441-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-02 | — | — | US | disclosed |
| US-20090069294-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20090069294-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069294-A1 | Organic Compounds | XIAP, BAX, MCL1 | XIAP 1/4885HPGD 2185/4885TSHR 4844/4885 |
| US-20110281845-A1 | ORGANIC COMPOUNDS | XIAP, BAX, MCL1 | XIAP 1/4885HPGD 2193/4885TSHR 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.