Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 10/20 | 0.68 |
| ▸ | CTSG | P08311 | 9/20 | 0.68 |
| ▸ | KLK14 | Q9P0G3 | 9/20 | 0.68 |
| ▸ | KLK5 | Q9Y337 | 9/20 | 0.68 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.68 |
| ▸ | ELANE | P08246 | 1/20 | 0.60 |
| ▸ | CTRC | Q99895 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10780103 | 0.85 | ELANE (0.77) | ELANENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL10781834 | 0.83 | ELANE (0.74) | ELANENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL18352966 | 0.81 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23187444 | 0.79 | KLK7 (0.58) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL18352894 | 0.78 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL4850801 | 0.78 | ELANE (0.66) | ELANENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL18352896 | 0.77 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL6121634 | 0.77 | ELANE (0.60) | ELANENPC1RAB9AALDH1A1USP2 | |
| SCHEMBL18353429 | 0.77 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL272702 | 0.76 | ELANE (1.00) | PRSS1ELANENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | ML Bio Solutions Inc. | 2024-02-29 | — | — | US | disclosed |
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | ML Bio Solutions Inc. | 2024-02-29 | — | — | US | disclosed |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20210101911-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | PHOENIX TISSUE REPAIR, INC. | 2021-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210101911-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.