Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.61 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501024 | 1.00 | CRBN (0.61) | CRBNOTUD7BBACE1NEK2HTR2A | |
| Hydrochloric Acid SCHEMBL18151735 | 0.98 | CRBN (0.59) | CRBNOTUD7BBACE1 | |
| Hydrochloric Acid SCHEMBL19032354 | 0.98 | CRBN (0.59) | CRBNOTUD7BBACE1 | |
| SCHEMBL1810656 | 0.89 | CRBN (0.50) | CRBNOTUD7BHTR2AHSD17B10 | |
| SCHEMBL30633804 | 0.89 | CRBN (0.50) | CRBNOTUD7BHTR2AHSD17B10 | |
| SCHEMBL12500998 | 0.89 | CRBN (0.55) | CRBNOTUD7BBACE1 | |
| SCHEMBL549600 | 0.89 | CRBN (0.50) | CRBNOTUD7BHTR2AHSD17B10 | |
| SCHEMBL20474650 | 0.88 | — | — | |
| SCHEMBL21238839 | 0.87 | CRBN (0.53) | CRBNOTUD7BBACE1 | |
| SCHEMBL21238838 | 0.87 | CRBN (0.48) | CRBNOTUD7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802544-A1 | PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES | RAPT Therapeutics, Inc. (US) | 2021-04-14 | — | — | EP | claimed |
| EP-3802544-A1 | PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES | RAPT Therapeutics, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |