Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24777445 | 0.96 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL15360309 | 0.94 | CYP2C9 (0.55) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL15127084 | 0.92 | CYP2C9 (0.53) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL29795067 | 0.91 | CYP2C9 (0.53) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL24777088 | 0.91 | CYP2C9 (0.49) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL8529911 | 0.90 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL20622309 | 0.90 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL23197883 | 0.90 | CYP2C9 (0.48) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL8530617 | 0.90 | CYP2C9 (0.59) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL24777438 | 0.90 | CYP2C9 (0.48) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402899-A1 | COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-12-22 | — | — | US | disclosed |
| WO-2021067528-A1 | COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402899-A1 | COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | CD4, HAVCR2, ASGR1 | CYP2C9 2127/4885CYP3A4 667/4885CYP2D6 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.