Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL10582698 | 0.97 | SLC7A5 (0.65) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL1764507 | 0.96 | SLC7A5 (0.63) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL28469095 | 0.96 | SLC7A5 (0.63) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL27515946 | 0.96 | SLC7A5 (0.63) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL18249967 | 0.94 | SLC7A5 (0.77) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL1537211 | 0.94 | SLC7A5 (0.77) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL302978 | 0.94 | SLC7A5 (0.77) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL302977 | 0.94 | SLC7A5 (0.77) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL5412770 | 0.94 | SLC7A5 (0.60) | SLC7A5PTGS1FOLH1ALPIPKM | |
| Tyrosine SCHEMBL28465791 | 0.94 | SLC7A5 (0.60) | SLC7A5PTGS1FOLH1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112384531-B | Binding molecules to BCMA and uses thereof | 诺华股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| US-20230295322-A1 | BINDING MOLECULES AGAINST BCMA AND USES THEREOF | NOVARTIS AG (CH) | 2023-09-21 | — | — | US | disclosed |
| EP-3802611-A2 | BINDING MOLECULES AGAINST BCMA AND USES THEREOF | Novartis AG (CH) | 2021-04-14 | — | — | EP | disclosed |
| CN-112384531-A | Binding molecules against BCMA and uses thereof | 诺华股份有限公司 | 2021-02-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295322-A1 | BINDING MOLECULES AGAINST BCMA AND USES THEREOF | EPCAM, CD40, BCR | ADORA3 2535/4885SLC7A5 3087/4885PTGS1 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.