Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29691301 | 1.00 | CHRM4 (0.49) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL23228633 | 0.88 | CHRM4 (0.46) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL23210298 | 0.87 | CHRM4 (0.52) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL23209974 | 0.86 | CHRM4 (0.49) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL29691232 | 0.86 | CHRM4 (0.49) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL23209975 | 0.86 | CHRM4 (0.49) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL23228632 | 0.86 | CHRM4 (0.51) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL29691221 | 0.85 | CHRM4 (0.57) | CHRM4CHRM1CHRM2CHRM5KDM1A | |
| SCHEMBL29844063 | 0.83 | CHRM4 (0.47) | CHRM4CHRM1CHRM2RORCCHRM5 | |
| SCHEMBL29843926 | 0.82 | CHRM4 (0.46) | CHRM4CHRM1CHRM2RORCCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548865-B2 | 2-azaspiro[3.4]octane derivatives as M4 agonists | NOVARTIS AG (CH) | 2023-01-10 | — | — | US | disclosed |
| US-20210107889-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2021-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107889-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | CHRM2, CHRM1, CHRM3 | CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885 |
| US-11548865-B2 | 2-azaspiro[3.4]octane derivatives as M4 agonists | CHRM2, CHRM1, CHRM3 | CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.