Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 20/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326832 | 1.00 | ADORA2A (0.62) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2326070 | 0.86 | ADORA2A (0.66) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2325797 | 0.77 | ADORA2A (0.71) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2319648 | 0.77 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2328712 | 0.74 | ADORA2A (0.80) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2326194 | 0.74 | ADORA2A (0.79) | ADORA2AADORA1ADORA2B | |
| SCHEMBL27881810 | 0.73 | ADORA1 (0.62) | ADORA2AADORA1ADORA2B | |
| SCHEMBL30186658 | 0.73 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2324215 | 0.73 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2320087 | 0.72 | ADORA2A (0.65) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531492-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | Heptares Therapeutics Limited (GB) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011095625-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | HEPTARES THERAPEUTICS LIMITED (GB) | 2011-08-11 | — | — | WO | disclosed |