SCHEMBL23211136

SCHEMBL23211136

COc1cc2c(nc1-c1cccc(C)c1C)c(I)nn2C(=O)OC(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CTSA P10619 5/20 0.36
PDE1A P54750 1/20 0.35
PDE1B Q01064 1/20 0.35
PDE1C Q14123 1/20 0.35
MAP2K4 P45985 1/20 0.34
NUDT1 P36639 3/20 0.33
SUV39H2 Q9H5I1 1/20 0.33
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
BRD4 O60885 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
GAA P10253 1/20 0.31
LMNA P02545 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29907005 1.00 CTSA (0.36) CTSAPDE1APDE1BPDE1CMAP2K4
SCHEMBL25737776 0.90 PDE1A (0.43) CTSAPDE1APDE1BPDE1CMAP2K4
SCHEMBL23211064 0.87 CTSA (0.41) CTSAPDE1APDE1BPDE1CNUDT1
SCHEMBL23210973 0.86 NR1H2 (0.35) PDE1APDE1BPDE1CMAP2K4SUV39H2
SCHEMBL30308807 0.86 NR1H2 (0.35) PDE1APDE1BPDE1CMAP2K4SUV39H2
SCHEMBL29907136 0.86 NR1H2 (0.35) PDE1APDE1BPDE1CMAP2K4SUV39H2
SCHEMBL23210982 0.84 MEN1 (0.35) PDE1APDE1BPDE1CMAP2K4SUV39H2
SCHEMBL29907071 0.84 MEN1 (0.35) PDE1APDE1BPDE1CMAP2K4SUV39H2
SCHEMBL23236625 0.82 SUV39H2 (0.32) MAP2K4SUV39H2BRD4NPC1RAB9A
SCHEMBL23211129 0.82 JAK2 (0.34) PDE1APDE1BPDE1CMAP2K4SUV39H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2025-02-20 US disclosed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 US disclosed
WO-2023122134-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF INCYTE CORPORATION (US) 2023-06-29 WO disclosed
WO-2023122134-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF INCYTE CORPORATION (US) 2023-06-29 WO disclosed
US-20230192722-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF INCYTE CORPORATION 2023-06-22 US disclosed
US-20230192722-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF INCYTE CORPORATION 2023-06-22 US disclosed
US-20230192722-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF INCYTE CORPORATION 2023-06-22 US disclosed
CN-115835908-A Bicyclic heterocycles as FGFR inhibitors 因赛特公司 2023-03-21 CN disclosed
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2023-03-21 US disclosed
EP-4045151-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS Incyte Corporation (US) 2022-08-24 EP disclosed
WO-2021076602-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION (US) 2021-04-22 WO disclosed
WO-2021076602-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION (US) 2021-04-22 WO disclosed
US-20210106588-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2021-04-15 US disclosed
US-20210106588-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2021-04-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 CTSA 4627/4885PDE1A 4140/4885PDE1B 4031/4885
US-20210106588-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 CTSA 4627/4885PDE1A 4140/4885PDE1B 4031/4885
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 CTSA 4627/4885PDE1A 4140/4885PDE1B 4031/4885
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 CTSA 4627/4885PDE1A 4140/4885PDE1B 4031/4885
US-20230192722-A1 SALTS AND SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES OF PREPARING THEREOF FGFR1, FGFR3, FGFR4 CTSA 4663/4885PDE1A 3409/4885PDE1B 3662/4885
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 CTSA 4627/4885PDE1A 4140/4885PDE1B 4031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.