Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 9/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29871416 | 1.00 | CHRM4 (0.55) | CHRM4CHRM1CHRM2CHRM5PTGDR2 | |
| SCHEMBL23230129 | 0.96 | CHRM4 (0.58) | CHRM4CHRM1CHRM2CHRM5PTGDR2 | |
| SCHEMBL23295184 | 0.96 | CHRM4 (0.58) | CHRM4CHRM1CHRM2CHRM5PTGDR2 | |
| SCHEMBL23213607 | 0.92 | CHRM4 (0.54) | CHRM4CHRM1CHRM2CHRM5PTGDR2 | |
| SCHEMBL23230138 | 0.91 | CHRM4 (0.58) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL23329016 | 0.89 | CHRM4 (0.58) | CHRM4CHRM1CHRM2GAATHRB | |
| SCHEMBL23213723 | 0.89 | CHRM4 (0.60) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL23213722 | 0.89 | CHRM4 (0.60) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL29619695 | 0.89 | CHRM4 (0.60) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL29619708 | 0.89 | CHRM4 (0.60) | CHRM4CHRM1CHRM2CHRM5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021070091-A1 | 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS AG (CH) | 2021-04-15 | — | — | WO | disclosed |