Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 18/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24872644 | 1.00 | DHODH (0.43) | DHODHSOS1RORC | |
| SCHEMBL29746564 | 1.00 | DHODH (0.43) | DHODHSOS1RORC | |
| SCHEMBL29512921 | 0.87 | DHODH (0.45) | DHODHRORC | |
| SCHEMBL20107676 | 0.87 | DHODH (0.45) | DHODHRORC | |
| SCHEMBL21462462 | 0.87 | DHODH (0.45) | DHODHRORC | |
| SCHEMBL26919109 | 0.85 | DHODH (0.47) | DHODH | |
| SCHEMBL20107634 | 0.85 | DHODH (0.43) | DHODHRORC | |
| SCHEMBL21435678 | 0.85 | DHODH (0.43) | DHODHRORC | |
| SCHEMBL29512864 | 0.85 | DHODH (0.43) | DHODHRORC | |
| SCHEMBL23056782 | 0.84 | KDM4E (0.44) | DHODHRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041714-A1 | BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2022070069-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2022-04-07 | — | — | WO | disclosed |
| CN-114286813-A | Substituted urea dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-04-05 | — | — | CN | disclosed |
| WO-2021070132-A1 | BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-04-15 | — | — | WO | disclosed |