SCHEMBL23216554

SCHEMBL23216554

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(OCC[Si](C)(C)C)ncnc43)C[C@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMP P19971 11/20 0.57
HIF1A Q16665 1/20 0.42
ADORA1 P30542 2/20 0.40
POLB P06746 1/20 0.39
ENPP1 P22413 1/20 0.39
P2RY1 P47900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29709107 1.00 TYMP (0.57) TYMPHIF1AADORA1POLBENPP1
SCHEMBL18486374 0.94 TYMP (0.59) TYMPHIF1AADORA1POLBENPP1
SCHEMBL18486211 0.87 TYMP (0.54) TYMPHIF1AADORA1POLBENPP1
SCHEMBL29574745 0.87 TYMP (0.63) TYMPHIF1AADORA1POLBENPP1
SCHEMBL1774839 0.87 TYMP (0.63) TYMPHIF1AADORA1POLBENPP1
SCHEMBL18486220 0.87 TYMP (0.62) TYMPHIF1AADORA1POLBENPP1
SCHEMBL1774838 0.87 TYMP (0.63) TYMPHIF1AADORA1POLBENPP1
SCHEMBL7871248 0.87 TYMP (0.63) TYMPHIF1AADORA1POLBENPP1
SCHEMBL29529385 0.87 TYMP (0.63) TYMPHIF1AADORA1POLBENPP1
SCHEMBL18486343 0.85 TYMP (0.52) TYMPHIF1AADORA1POLBENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220384-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-07-13 US disclosed
EP-4022059-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF Wave Life Sciences Ltd. (SG) 2022-07-06 EP disclosed
WO-2021071858-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2021-04-15 WO disclosed