Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29591076 | 1.00 | MAPT (0.57) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL23219102 | 0.83 | MEN1 (0.40) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL29591158 | 0.83 | MEN1 (0.40) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL29592686 | 0.82 | MAPT (0.56) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL23219141 | 0.82 | MAPT (0.56) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL23218859 | 0.78 | MAOB (0.55) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL29591281 | 0.73 | HTR2A (0.35) | CYP3A4ALOX15ALDH1A1 | |
| SCHEMBL23219021 | 0.73 | HTR2A (0.35) | CYP3A4ALOX15ALDH1A1 | |
| SCHEMBL15296183 | 0.73 | GAA (1.00) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL23218782 | 0.72 | HTR2A (0.36) | CYP3A4ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |