Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | IGF2BP1 | Q9NZI8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cucurbitacin I SCHEMBL19679893 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL8738868 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL15914446 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL10013366 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL23999338 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL20121526 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL2523066 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL23219974 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL22791196 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 | |
| Cucurbitacin I SCHEMBL19236029 | 1.00 | ITGAL (1.00) | ITGALPAX8SMN1; SMN2HIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10973913-B2 | JAK inhibitors and uses thereof | WASHINGTON UNIVERSITY (US) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10973913-B2 | JAK inhibitors and uses thereof | JAK2, JAK1, JAK3 | ITGAL 2136/4885PAX8 4618/4885SMN1; SMN2 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.