Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sertraline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.97 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | GMNN | O75496 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.97 |
| ▸ | NPC1 | O15118 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sertraline SCHEMBL5741903 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL6701905 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL29406979 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL29895228 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL3866334 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL7327367 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL4963372 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL1560715 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL33371 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT | |
| Sertraline SCHEMBL4620487 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20023 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719341-A1 | AN ORALLY DISINTEGRATING TABLET OF SERTRALINE AND ITS PROCESS OF PREPARATION | Novumgen Limited (GB) | 2026-04-08 | — | — | EP | claimed |
| EP-3931189-B1 | AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | UNIV CALIFORNIA (US) | 2025-12-24 | — | — | EP | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250339483-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS THERAPEUTICS SAS (FR) | 2025-11-06 | — | — | US | claimed |
| US-20250319073-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUNTINGTON’S DISEASE AND HTT PROTEINOPATHIES | STEALTH BIOTHERAPEUTICS INC. (US) | 2025-10-16 | — | — | US | claimed |
| EP-4608424-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS Therapeutics SAS (FR) | 2025-09-03 | — | — | EP | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| CN-119455427-B | Sertraline hydrochloride tablet raw material processing device | 盐城市东港药物化工发展有限公司 | 2025-06-10 | — | — | CN | claimed |
| US-20250136548-A1 | FUNCTIONALIZED ALKYLAMINES | TERRAN BIOSCIENCES INC (US) | 2025-05-01 | — | — | US | claimed |
| CN-119838119-A | Victim emotion regulating system based on self-care | 郑州师范学院 | 2025-04-18 | — | — | CN | claimed |
| EP-0073291-A1 | Device for warming people, particularly those driving a motor vehicle | Roehr, Oskar W.K. (DE) | 1983-03-09 | — | — | EP | claimed |
| EP-0009891-B1 | DIRT COLLECTING FLOOR MAT APPARATUS | Spirig, Ernst (CH) | 1982-09-29 | — | — | EP | claimed |
| EP-0011983-B1 | REGENERATIVE ROTODYNAMIC MACHINES | CompAir Industrial Limited (GB) | 1982-05-26 | — | — | EP | claimed |
| EP-0051714-A1 | Clothing articles such as jackets, parkas, overalls, coats, blousons or the like for heating drivers of motor vehicles | Roehr, Oskar W.K. (DE) | 1982-05-19 | — | — | EP | claimed |
| EP-0049786-A1 | Seat spring system | DEERE & COMPANY (US) | 1982-04-21 | — | — | EP | claimed |
| EP-0006072-B1 | IN WIDTH AND HEIGHT AUTO-EXTENSIBLE CARAVAN | Loniewski, Robert Alfred Antoine Marie (FR) | 1981-07-01 | — | — | EP | claimed |
| EP-0020414-A1 | DEVICE FOR PRESENTING OPAQUE IMAGES, FOR EXAMPLE PHOTOS | REFLECTA GMBH FOTO FILM PROJEKTION (DE) | 1981-01-07 | — | — | EP | claimed |
| EP-0020413-A1 | SAFETY DEVICE FOR PIN WITH SELF-LOCKING TO PREVENT A RADIAL DISPLACEMENT. | SPRINGFIX BEFESTIGUNGSTECHNIK (DE) | 1981-01-07 | — | — | EP | claimed |
| WO-1980000622-A1 | DEVICE FOR PRESENTING OPAQUE IMAGES,FOR EXAMPLE PHOTOS | REFLECTA GMBH FOTO (DE) | 1980-04-03 | — | — | WO | claimed |
| WO-1980000603-A1 | SAFETY DEVICE FOR PIN WITH SELF-LOCKING TO PREVENT A RADIAL DISPLACEMENT | SPRINGFIX BEFESTIGUNGSTECHNIK (DE) | 1980-04-03 | — | — | WO | claimed |