Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374251 | 0.84 | LCK (0.69) | LCKCYP3A4FGFR3CYP2C19CYP2C9 | |
| SCHEMBL374267 | 0.70 | LCK (0.76) | LCKCYP3A4FGFR3CYP2C19CYP2C9 | |
| SCHEMBL374265 | 0.70 | TNNI3K (0.56) | EGFRABCG2F9 | |
| SCHEMBL374719 | 0.69 | LCK (0.73) | LCKCYP3A4FGFR3CYP2C19CYP2C9 | |
| SCHEMBL374686 | 0.67 | LCK (0.72) | LCKCYP3A4FGFR3CYP2C19CYP2C9 | |
| SCHEMBL13855375 | 0.66 | LCK (0.58) | LCKCYP3A4FGFR3CYP2C19EGFR | |
| SCHEMBL374147 | 0.65 | LCK (1.00) | LCKCYP3A4FGFR3CYP2C19 | |
| SCHEMBL374072 | 0.65 | LCK (0.62) | LCKCYP3A4FGFR3CYP2C19CYP2C9 | |
| SCHEMBL374236 | 0.65 | LCK (0.79) | LCKCYP3A4FGFR3CYP2C19 | |
| SCHEMBL27320738 | 0.64 | KDM1A (0.48) | CYP2C19EGFRABCG2IRAK4F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |