⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908763 | 0.84 | — | — | |
| SCHEMBL30753323 | 0.84 | — | — | |
| SCHEMBL19509973 | 0.80 | — | — | |
| SCHEMBL12511174 | 0.78 | — | — | |
| SCHEMBL21315206 | 0.76 | — | — | |
| SCHEMBL21975274 | 0.69 | — | — | |
| SCHEMBL20646581 | 0.67 | — | — | |
| SCHEMBL21976161 | 0.66 | — | — | |
| SCHEMBL21316207 | 0.66 | — | — | |
| SCHEMBL15355223 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492194-B2 | HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-09 | — | — | US | disclosed |
| EP-4655298-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS | Theras Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| US-20250325660-A1 | IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE | INCYTE CORP (US) | 2025-10-23 | — | — | US | disclosed |
| EP-3947366-B1 | HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-21 | — | — | EP | disclosed |
| US-20250154153-A1 | DIHYDROIMIDAZO-PYRIMIDINONE COMPOUNDS AS LP-PLA2 INHIBITORS AND USE THEREOF | 4B TECHNOLOGIES (BEIJING) CO., LIMITED (CN) | 2025-05-15 | — | — | US | disclosed |
| WO-2025054431-A1 | BENZO-FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF | XENON PHARMACEUTICALS INC. (CA) | 2025-03-13 | — | — | WO | disclosed |
| WO-2024158778-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS | THERAS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |
| US-20240182465-A1 | FUSED RING SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2024-06-06 | — | — | US | disclosed |
| EP-4303216-A1 | FUSED RING SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-01-10 | — | — | EP | disclosed |
| US-20230339947-A1 | USE OF CASEINOLYTIC PROTEASE P FUNCTION AS A BIOMARKER OF DRUG RESPONSE TO IMIPRIDONE-LIKE AGENTS | Madera Therapeutics, LLC | 2023-10-26 | — | — | US | disclosed |
| CN-102203077-B | (pyrrolidin-2-yl) phenyl derivatives for the treatment of pain | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | disclosed |
| WO-2014028669-A1 | NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY | BIOGEN IDEC MA INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| US-8227480-B2 | Indazole derivative having spiro ring structure in side chain | UBE INDUSTRIES, LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| EP-2356105-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. Organon (NL) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010052198-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. ORGANON (NL) | 2010-05-14 | — | — | WO | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| US-20090170887-A1 | Novel indazole derivative having spiro ring structure in side chain | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-2025676-A1 | NOVEL INDAZOLE DERIVATIVE HAVING SPIRO RING STRUCTURE IN SIDE CHAIN | Ube Industries, Ltd. (JP) | 2009-02-18 | — | — | EP | disclosed |