Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29383322 | 0.96 | ACACB (0.39) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL29380981 | 0.96 | SYK (0.40) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23246709 | 0.89 | PIK3R1 (0.39) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23246482 | 0.89 | NAMPT (0.47) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23247649 | 0.88 | ACACB (0.39) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23246656 | 0.87 | PIK3CA (0.43) | PIK3R1PIK3CAPIK3CDPIK3CBUSP30 | |
| SCHEMBL23246672 | 0.86 | ACACB (0.38) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23247157 | 0.84 | PIK3R1 (0.38) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23247235 | 0.84 | MAP3K12 (0.45) | ACACBPIK3R1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL23246834 | 0.84 | PIK3R1 (0.36) | PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021074279-A1 | SPIRO-FUSED TRICYCLIC MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-22 | — | — | WO | claimed |
| WO-2021074279-A1 | SPIRO-FUSED TRICYCLIC MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-22 | — | — | WO | disclosed |
| WO-2021074279-A1 | SPIRO-FUSED TRICYCLIC MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-22 | — | — | WO | disclosed |